Glutathione
Recent research & studies
- Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma
This phase III trial tests whether adding trastuzumab and hyaluronidase-oysk (Herceptin Hylecta [TM]) or pertuzumab, trastuzumab and hyaluronidase-zzxf (Phesgo [TM]) to the usual chemotherapy (paclitaxel and carboplatin) works to shrink tumors in patients with HER2 positive endometrial cancer. Trastuzumab and…
- Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer
This phase III trial compares the effect of bevacizumab in combination with carboplatin, paclitaxel and pembrolizumab to the usual treatments of carboplatin and paclitaxel with or without pembrolizumab in treating patients with stage III, IVA or IVB mismatch repair protein…
- Study on the Effect of Hyperbaric Oxygen Intervention on Relieving Sports Fatigue of Sailors
1. Research Purpose Intensive training often causes autonomic nerve imbalance, poor microcirculation and slow fatigue recovery in elite sailing athletes. This study adopted 1.3 ATA mild hyperbaric oxygen with 28% oxygen concentration for a 6-week intervention. It aimed to explore…
- Serum Ferroptosis Biomarkers (GPX4, MDA) in Alopecia Areata
This study aims to investigate the potential role of the ferroptosis pathway in the pathogenesis and clinical course of Alopecia Areata (AA). Serum concentrations of two key ferroptosis biomarkers-Glutathione Peroxidase 4 (GPX4), a primary antioxidant enzyme protecting against lipid peroxidation,…
- NCI COVID-19 in Cancer Patients, NCCAPS Study
This study collects blood samples, medical information, and medical images from patients who are being treated for cancer and have a positive test for SARS CoV-2, the new coronavirus that causes the disease called COVID-19. Collecting blood samples, medical information,…
- Structural insights into the structure-activity relationships of flavonoids targeting WSSV and LvGSTMu.
White spot syndrome virus (WSSV) represents one of the most severe threats to shrimp aquaculture worldwide, with no effective antiviral treatments currently available. In this study, the antiviral and antioxidant potential of the flavonoids amentoflavone, agathisflavone, and apigenin was investigated…
- Metal-siloxanes derived bio-inspired superhydrophobicity and nitric oxide generation for anti-biofouling clinical applications.
Bio-inspired superhydrophobic surfaces are widely investigated for antibiofouling applications; however, they lack intrinsic bioactivity and provide passive resistance without eliminating planktonic or surface-adhered microbes. In this work, superhydrophobicity is integrated with bioactive nitric oxide (NO) generation from physiological levels of…
- Transcriptomic and Single-Cell Analyses Reveal a Prognostic Mitochondria- and Immunity-Related Risk Signature in Osteosarcoma.
Background: While mitochondrial dysfunction and immune cell dysregulation have been established as important contributors to the pathogenesis of osteosarcoma (OS), the prognostic value of mitochondria-related genes (MRGs) and immune-related genes (IRGs) in OS remains poorly understood. Methods: Data were obtained…
- The miR-339-5p/ACSL4 Pathway Drives Ferroptosis in Macrophages Exposed to Silica Nanoparticles.
Background: The widespread application of silica nanoparticles (SiNPs) in industrial fields has raised increasing concerns regarding their potential biological toxicity. However, the cellular mechanisms underlying SiNPs-related injury remain incompletely understood. This study was designed to investigate whether ferroptosis contributes to…
- MGST1 Suppresses Ferroptosis in Nucleus Pulposus Cells and Attenuates Intervertebral Disc Degeneration by Regulating GPX4.
Background: Intervertebral disc degeneration (IDD) is a major pathological contributor to low back pain, and its progression is closely associated with oxidative stress and cell death. Ferroptosis is a form of programmed cell death characterized by iron-dependent lipid peroxidation, which…
These are third-party research studies presented for informational purposes. They are not endorsements and do not constitute medical advice or claims about any product.
