Kisspeptin
Recent research & studies
- Maternal-Neonatal Metabolic Continuity and Early Postnatal HPG Axis Activity in Healthy Term Neonates.
Background: Leptin integrates metabolic and reproductive signaling later in life; however, whether maternal metabolic cues influence early neonatal hypothalamic-pituitary-gonadal (HPG) axis activity remains unclear. Objective: To evaluate associations between maternal metabolic markers and early neonatal reproductive hormone activity. Methods: Forty…
- Role of KNDy neurons in the negative-feedback suppression of gonadotropin secretion in female rats.
The hypothalamic neurons that coexpress kisspeptin, neurokinin B, and dynorphin (KNDy) play a crucial role in the control of gonadotropin-releasing hormone (GnRH) pulsatile release and, thereby, in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion. However, the feedback mechanism of…
- Ambient Air Pollution, Polycyclic Aromatic Hydrocarbons, and Pubertal Development: A Critical Review of Emerging Evidence.
Purpose Of Review: Puberty is a sensitive period of endocrine development with lifelong implications for cardiometabolic and reproductive health. This review evaluates evidence linking ambient air pollution and polycyclic aromatic hydrocarbons (PAHs) to pubertal development. Recent Findings: Studies suggest that…
- Naringenin protects against renal ischemia-reperfusion injury following unilateral nephrectomy via modulation of oxidative stress and kisspeptin expression.
Background: Renal ischemia-reperfusion (IR) injury is a major cause of acute kidney injury, mediated by oxidative stress (OS), inflammation, and apoptosis. Naringenin (NRG), a citrus flavonoid, exerts antioxidant and anti-apoptotic actions, yet its role in renal kisspeptin signaling during IR…
- Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease
The objective of this protocol is to use a case-control paradigm to compare the response to an intravenous administration of kisspeptin in individuals with and without post-covid-19 syndrome. The study subjects will receive a single bolus of kisspeptin.
- The Molecular Basis of Inherited Reproductive Disorders
The goal of this study is to learn more about the genes that control puberty and reproduction in humans.
- Kisspeptin Administration Subcutaneously to Patients With IHH
The goal of this study is to see whether kisspeptin, a naturally occurring hormone, can stimulate the release of other reproductive hormones in men and women with idiopathic hypogonadotropic hypogonadism (IHH). The investigators are also examining whether kisspeptin can help…
- Kisspeptin Administration Subcutaneously to Patients With Hypothalamic Amenorrhea
The goal of this study is to see whether kisspeptin, a naturally occurring hormone, can stimulate the release of other reproductive hormones in women with hypothalamic amenorrhea (HA). The investigators are also examining whether kisspeptin can help women release eggs…
- Kissing as a Protective Factor Against Acidic pH in Saliva
The pH of saliva can be acidic or alkaline; When it is acidic, the tooth enamel is demineralized, that is, weakened. Additionally, bacteria in the mouth can increase and cause infections such as cavities. This occurs when we consume sugary…
- A brain-first framework for perimenopause management: the case for non-invasive neuromodulation.
The menopause transition affects approximately half the global population yet remains substantially under-researched and under-treated. Standard care is dominated by menopausal hormone therapy (MHT), with adjunctive use of selective serotonin and noradrenaline reuptake inhibitors and, more recently, neurokinin-3 receptor antagonists.…
These are third-party research studies presented for informational purposes. They are not endorsements and do not constitute medical advice or claims about any product.
