KPV
Recent research & studies
- KPV attenuates adipogenesis and lipid metabolism through modulation of ROS-mediated AKT/mTORC1/PPARγ signaling.
Lysine-Proline-Valine (KPV), an endogenous tripeptide derived from α-melanocyte-stimulating hormone, has been recognized for its anti-inflammatory and antioxidant activities. However, its role in adipocyte differentiation has not been investigated. In this study, we investigated the regulatory effects of KPV on MDI-induced…
- Short Cationic ACTH-Related Peptides Can Modulate the Na(V)1.8 Channel Functioning, Resulting in an Analgesic Effect.
Full-length ACTH molecule and ACTH-related hexapeptide H-PKKRRP-OH are demonstrated by the patch-clamp method to decrease the NaV1.8 channel activation gating system effective charge in the nociceptive neuron membrane, while ACTH-related tetrapeptide Ac-KKRR-NH2 has no effect. ACTH(1-24), a fully functional ACTH…
- Pediatric Neuroinflammatory and Neuropsychiatric Syndromes Associated with Dupilumab Treatment for Atopic Dermatitis.
Dupilumab, a monoclonal antibody blocking interleukin-4/interleukin-13 signaling, was associated with neuroinflammatory syndromes in 4 children treated for atopic dermatitis. Individuals exhibited behavioral changes, language impairment, and neurodiagnostic abnormalities 2-6 months after treatment initiation. Three improved with drug discontinuation and immunomodulatory…
- Impact of cationic, anionic, and amphiphilic emulsifiers on the physicochemical properties and applications of xanthan gum-shea butter bigels.
Bigels (BGs) have gained significant interest as versatile semisolid systems capable of immobilising both hydrophilic and lipophilic phases, making them suitable carriers for drug delivery. The current paper discusses the formulation of bigels (BGs) by combining xanthan gum (XG) based…
- Correlation of Lung Texture Analysis by Computer-Aided Lung Informatics for Pathology Evaluation and Rating (CALIPER) With High-Resolution Computed Tomography and Lung Function in Fibrosing Interstitial Lung Diseases.
Background Progressive pulmonary fibrosis (PPF) is characterized by worsening symptoms, physiological decline (forced vital capacity (FVC) or diffusing capacity for carbon monoxide), and/or radiological progression within a year. It can develop in patients with fibrosing interstitial lung diseases (ILDs), including idiopathic…
These are third-party research studies presented for informational purposes. They are not endorsements and do not constitute medical advice or claims about any product.
