MOTS-C
Recent research & studies
- Mitochondria-derived peptide hydrogel augments mitochondrial transplantation for promoting cardiac repair via macrophage metabolic reprogramming.
Myocardial infarction (MI) is characterized by severe oxidative stress, excessive inflammation, and profound mitochondrial dysfunction. Although mitochondrial transplantation offers therapeutic promise for MI, its clinical translation is severely hampered by the extreme fragility of donor mitochondria with rapid loss of…
- MOTS-c in sepsis-induced cardiomyopathy: Mechanisms and translational potential.
Sepsis-induced cardiomyopathy (SICM) is a prevalent cardiac complication of sepsis that is characterized by inflammatory dysregulation, mitochondrial dysfunction, metabolic disturbance, and changes in the myocardial microenvironment. Mitochondrial open reading frame of the 12S rRNA type-c (MOTS-c) is a mitochondrial-derived microprotein…
- Efficacy of 99Tc-MDP combined with electroacupuncture of hip acupoints for delaying the progression of osteonecrosis of the femoral head.
- An In-vivo Survival Rate of Different Onlay Materials Placed Over Endodontically Treated Molar Teeth
This study aims to evaluate the survival rates of onlays placed over posterior endodontically treated teeth restored with zirconia, lithium disilicate and lithium disilicate reinforced with zirconia. Additionally, it seeks to identify and assess the failure modes associated with these…
- Breast Cancer Molecular Subtypes and Skeletal Metastases Patterns on Bone Scintigraphy
The goal of this observational study is to evaluate the association between different molecular subtypes of breast cancer and their specific patterns of skeletal metastases on Technetium-99m MDP bone scintigraphy. The study will include adult male and female patients aged…
- Ecstasy to Alleviate SEvere Chronic Neuropathic Pain Trial
This is a Health Canada regulated internal pilot study designed to assess the feasibility, tolerability, and preliminary efficacy of 3, 4-methylenedioxymethamphetamine hydrochloride capsules-AT for chronic neuropathic pain to inform a larger, fully powered multi-center study. This is an interventional, randomized,…
- Safety and Usability of the Inga Catheter for Labor Induction (INGA-MDP)
The goal of this clinical study is to evaluate a new mechanical balloon catheter (INGA) used to prepare the cervix for labor induction in pregnant women at term. The study aims to assess the safety, usability, and performance of the…
- Marginal Biofilm Distribution and Periodontal Response to Supragingival and Juxtagingival Aligner Designs
* This prospective, longitudinal, within-person (split-mouth) clinical study evaluates the influence of two clear aligner trimming-line designs on marginal soft-tissue biofilm distribution and periodontal tissue response over a six-month period. * Two trimming-line designs are compared. The supragingival design has…
- Intra-positional technical performance under different physical demands in elite football: a comparison between most demanding passage and extremely demanding passage.
Introduction: This study investigated positional differences in technical performance between the Most Demanding Passage (MDP) and the Extremely Demanding Passage (EDP) in elite football. EDP was defined as the top 5% of match phases based on position-specific high-intensity running (HIR)…
- Automatic therapy planning based on concept drift.
Static rehabilitation protocols often struggle to keep pace with the dynamic, non-linear reality of human motor recovery. Traditional therapy models frequently assume stationarity, relying on fixed performance schemes that fail to capture the highly individualized nature of human recovery and…
These are third-party research studies presented for informational purposes. They are not endorsements and do not constitute medical advice or claims about any product.
