MT-2
Recent research & studies
- Photoactivated iridium(III) complexes drive pyroptosis-necroptosis synergy for multi-network photoimmunotherapy of renal cell carcinoma.
Recurrence and metastasis are the leading causes of mortality in renal cell carcinoma (RCC), and its intrinsic drug resistance further limits effective therapeutic options. Synergistic activation of multiple regulated cell death pathways has recently emerged as a novel approach to…
- Combined effects of melatonin and valproic acid in cerebral ischemia via modulation of oxidative stress and melatonin receptors.
Background: Ischemic stroke is a major cause of mortality and disability worldwide, with limited effective neuroprotective treatments. Epigenetic modulation and oxidative stress regulation have emerged as promising therapeutic targets. This study aimed to evaluate the neuroprotective effects of melatonin and…
- Functional delivery of commercially-available microRNA mimics to the organs of developing mice.
MicroRNA are pivotal regulators of organ and tissue homeostasis and development, and pathogenic mediators of disease. While antagonism of specific microRNA species in vivo is easily accomplished in experimental animal models using locked nucleic acid (LNA)-stabilized antimiRs, microRNA mimicry -that…
- Exploring the Use of Genetic and Behavioural Data in Tailoring Dietary and Lifestyle Support
Personalised nutrition approaches typically rely on static information such as health status, lifestyle and genetic data. However, adherence often remains low because daily behaviours are influenced by psychological states, motivation and real-time barriers. There is growing interest in whether integrating…
- A Study to Evaluate Sapablursen (Formerly ISIS 702843, IONIS-TMPRSS6-LRx) in Patients With Polycythemia Vera
The main purpose of this study is to evaluate the efficacy of sapablursen in reducing the frequency of phlebotomy and in improving quality of life assessments in participants with polycythemia vera.
- A Study to Test the Safety, Tolerability, and Efficacy of an Antibody, REGN7999, Injected Under the Skin for the Treatment of Iron Overload in Adult Participants With Non-Transfusion Dependent β-thalassemia, Using MRI Scans to Measure Iron Levels in the Body
This study is researching an experimental drug called REGN7999 (called "study drug"). The study is focused on patients with non-transfusion dependent beta-thalassemia. The aim of the study is to see how safe and effective the study drug is. The study…
- Effectiveness of Instrumental Assisted Soft Tissue Mobilization Versus Conventional Treatment on Administrative Staff for Text Neck Syndrome
The goal of this randomize control trial is to compare two interventions to treat text neck syndrome on administrative staff. The main questions it aims to answer are: * There is no significant difference in outcomes between instrumental assisted mobilizations…
- Melanotan II (MT-II) as an Adjunct to NB-UVB Phototherapy for Repigmentation in Stable Nonsegmental Vitiligo
This example interventional study record describes a randomized Phase 2 clinical trial evaluating investigational Melanotan II (MT-II) as an adjunct to standard NB-UVB phototherapy for repigmentation in adults with stable nonsegmental vitiligo.
- Panax notoginseng saponins alleviates metabolic dysfunction-associated steatotic liver disease in mice by influencing Nrf2/MT2.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a metabolic liver injury driven largely by oxidative stress. The nuclear factor erythroid 2-related factor 2 (Nrf2) pathway plays a central role in antioxidant defense, and metallothionein-2 (MT2) is a potential downstream…
- How close is too close for singular mean curvature flows?
Suppose ( M t i ) t ∈ [ 0 , T ) , i = 1 , 2 , are two mean curvature flows in R n + 1 encountering a multiplicity one compact singularity at time T, in…
These are third-party research studies presented for informational purposes. They are not endorsements and do not constitute medical advice or claims about any product.
