MT-2
Recent research & studies
- "Mary thinks that John thinks that…" Developmental change and individual stability in attributing second-order mental states in 5 to 7-year-olds.
Second-order understanding of mental states develops during middle childhood. However, due to the limited number of longitudinal studies on this topic, the timing of developmental changes and the stability of individual performance remain insufficiently explored. The current study examined the…
- Loss of eIF3m aggravates myocardial ischemia/reperfusion injury via enhancing nitrative damage and inhibiting glycolytic reprogramming.
The reprogramming of myocardial energy metabolism is critical for cardiac repair after ischemia/reperfusion (I/R) injury, yet the upstream translational control mechanisms remain elusive. Here, through multi-omics analysis of human failing hearts, we identify the mRNA regulator eIF3m as an essential…
- Impact of Keratinized Mucosa Width and Mucosal Thickness on Implant Outcomes and Brushing Discomfort: A 25-Year Cohort Study.
Objective: To assess the impact of keratinized mucosa width (KMW) and mucosal thickness (MT) on peri-implant conditions over 25 years in patients with adequate oral hygiene enrolled in regular supportive peri-implant care. Methods: Partially edentulous patients rehabilitated with tissue-level implants were…
- Variation in resistance and survival of the European bitterling fish across a gradient of Sinanodonta woodiana expansion.
Biological invasions impose new selective pressures on native species, prompting rapid evolutionary responses. We examined how the parasitic larvae (glochidia) of the invasive East Asian mussel Sinanodonta woodiana affect European bitterling fish (Rhodeus amarus) populations with different histories of exposure…
- Host-microbe Interactions in the Appendix of Children with Inflammatory Bowel Diseases.
The human appendix is traditionally considered a vestigial organ; however, clinical observations link it to inflammatory bowel diseases (IBD), including Crohn disease and ulcerative colitis (UC), as suggested by peri-appendicular inflammation and reported protective effect of appendectomy in UC. Despite…
- Exploring the Use of Genetic and Behavioural Data in Tailoring Dietary and Lifestyle Support
Personalised nutrition approaches typically rely on static information such as health status, lifestyle and genetic data. However, adherence often remains low because daily behaviours are influenced by psychological states, motivation and real-time barriers. There is growing interest in whether integrating…
- A Study to Evaluate Sapablursen (Formerly ISIS 702843, IONIS-TMPRSS6-LRx) in Patients With Polycythemia Vera
The main purpose of this study is to evaluate the efficacy of sapablursen in reducing the frequency of phlebotomy and in improving quality of life assessments in participants with polycythemia vera.
- A Study to Test the Safety, Tolerability, and Efficacy of an Antibody, REGN7999, Injected Under the Skin for the Treatment of Iron Overload in Adult Participants With Non-Transfusion Dependent β-thalassemia, Using MRI Scans to Measure Iron Levels in the Body
This study is researching an experimental drug called REGN7999 (called "study drug"). The study is focused on patients with non-transfusion dependent beta-thalassemia. The aim of the study is to see how safe and effective the study drug is. The study…
- Effectiveness of Instrumental Assisted Soft Tissue Mobilization Versus Conventional Treatment on Administrative Staff for Text Neck Syndrome
The goal of this randomize control trial is to compare two interventions to treat text neck syndrome on administrative staff. The main questions it aims to answer are: * There is no significant difference in outcomes between instrumental assisted mobilizations…
- Melanotan II (MT-II) as an Adjunct to NB-UVB Phototherapy for Repigmentation in Stable Nonsegmental Vitiligo
This example interventional study record describes a randomized Phase 2 clinical trial evaluating investigational Melanotan II (MT-II) as an adjunct to standard NB-UVB phototherapy for repigmentation in adults with stable nonsegmental vitiligo.
These are third-party research studies presented for informational purposes. They are not endorsements and do not constitute medical advice or claims about any product.
